• ABT-199 (Venetoclax): Mechanistic Insights into Selective...

  2025-09-18

  ABT-199 (Venetoclax), a potent and selective Bcl-2 inhibitor, provides unparalleled specificity for studying apoptosis mechanisms in hematologic malignancies. This article examines emerging mechanistic insights, including recent findings on nuclear-mitochondrial apoptotic signaling, and highlights optimized research applications for ABT-199.

• In summary the role of HT and differe http

  2025-03-03

  

  In summary, the role of 5-HT and different types of 5-HTRs in gating plasticity induction in neocortical circuits remains unclear, with variable and seemingly contradictory effects reported for LTP induction in cortical sensory fields (e.g., V1, enhanced LTP: Inaba et al., 2009, Kojic et al., 1997,

• br Materials and methods br

  2025-03-03

  

  Materials and methods Results The average body weights for each group of mice over the course of the study are shown in Fig. 2A. The average body weights of the mice in the saline control group and PACAP group increased slightly during the study. In contrast, starting at day 17, the body weigh

• PC is considered as a cancer of the epigenome Grasso

  2025-03-03

  

  PC is considered as a cancer of the epigenome (Grasso et al., 2012, Robinson et al., 2015). Our results demonstrate that the interaction of AR with ACK1 drives the positive feedback epigenetic circuitry that is ultimately conducive to promote AR transcription. Further, this circuitry subjugates AR t

• Introduction br This paper is a commentary on

  2025-03-03

  

  Introduction This paper is a commentary on the history of language among the Aché. What was language for the Aché prior to contact with Paraguayan society? How has the Aché language come to be endangered? Why is language such an important issue today? In exploring these questions I come to a slig

• Five alternatively spliced isoforms of ATX have

  2025-03-03

  

  Five alternatively-spliced isoforms of ATX have been described and all are catalytically active [16], [17]. The original ATX described in 1992 is termed ATXα, whereas the most abundant isoform is ATXβ and is the same isoform responsible for plasma lysoPLD activity [18]. Full length ATX is synthesize

• On the contrary evidence also suggests that autophagy plays

  2025-03-03

  

  On the contrary, evidence also suggests that autophagy plays a striking protective role in cancer cells. Highly burgeoning cancer 9-(2-Deoxy-β-D-ribofuranosyl)adenine require cellular building blocks for their metabolism and energy production. At this stage of cancer development, autophagy acts as

• br Introduction In addition to ATP

  2025-03-01

  

  Introduction In addition to ATP production, an important role of mitochondria in the pancreatic beta cell is anaplerosis, which is the net synthesis of citric rsv virus cycle intermediates that are exported to the cytosol where they are converted to numerous other metabolites that stimulate and/

• br ASK in multiple sclerosis and optic neuritis

  2025-03-01

  

  ASK1 in multiple sclerosis and optic neuritis Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system (CNS), is the most common neurological disease among young adults in the United States and Europe (Dutta and Trapp, 2011). Although MS primarily affect

• br Conclusion br Acknowledgments The authors extend their

  2025-03-01

  

  Conclusion Acknowledgments The authors extend their appreciation to Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University for funding this work through the research project Number (G-2016-2). Introduction L-ornithine is a natural

• Serum concentrations of APP and antioxidants of the queens

  2025-03-01

  

  Serum concentrations of APP and antioxidants of the 10 queens with pyometra before surgery (T0), at day two (T1) and at day 10 (T2) after ovariohysterectomy are presented in Fig. 1. Concentrations of SAA and Hp were significantly lower (P  correlations between the serum antioxidants Thiol, CUPRAC an

• br Methods for antifungal testing of mucorales species

  2025-03-01

  

  Methods for antifungal testing of mucorales species The Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST) reference methods currently in place for in vitro antifungal susceptibility testing of filamentous fungi [8], [9] have

• br Materials and methods br Results

  2025-03-01

  

  Materials and methods Results and discussion Conclusions Acknowledgements Introduction Infections in children aged 0–21 years who reside in long-term care (LTC) facilities are common due to underlying complex medical conditions, use of invasive devices such as urinary catheters and ve

• Dual acting RAAS blockade and neprilysin inhibition has

  2025-03-01

  

  Dual-acting RAAS blockade and neprilysin inhibition has been evaluated in several clinical HF trials. In PARADIGM-HF [6,7], LCZ696 was superior to enalapril in reducing mortality and HF hospitalizations in symptomatic patients with HF with reduced EF. Augmented benefits on maladaptive cardiac remode

• In this report we introduce a new method for

  2025-03-01

  

  In this report, we introduce a new method for identifying aminopeptidases. Because single substrates can be insufficient for enzyme identification, we used an entire library of substrates to obtain more information about enzyme activity and to directly detect aminopeptidases. Moreover, substrates c

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