• We neither observed changes in midazolam eCLmet indicative o

  2019-10-12

  

  We neither observed changes in midazolam eCLmet indicative of significant inhibition of CYP3A4/5 during both experiments, despite the in vitro evidence for CYP3A4/5 inhibition (Theile et al., 2017). The observed increase in CYP3A dependent midazolam clearance after chronic ingestion of clementines/c

• Neuroinflammation is the one of the emerging

  2019-10-12

  

  Neuroinflammation is the one of the emerging causal factors contributing to these cognitive deficits. Therefore, we further tested the hypothesis that neuroinflammation is a key component contributing to the progression of spatial memory deficits during HH. Spatial memory deficits were observed afte

• Almost all previously published haplotype association

  2019-10-12

  

  Almost all previously published haplotype association studies have demonstrated the importance of haplotype reconstruction because the combinations of SNPs exert synergistic effects on protein function. Even synonymous polymorphisms within haplotypes can have functional consequences that are drastic

• Introduction Angiotensin II Ang II and Endothelin

  2019-10-12

  

  Introduction Angiotensin II (Ang II) and Endothelin 1 (ET-1) are potent vasoconstrictive peptides recognized as key players in many cardiovascular diseases [1]. Cardiac hypertrophy, ischemic arrhythmia, and stroke have been associated to an overstimulation of the angiotensin II type 1 (AT1) recepto

• In our previous research we have focused

  2019-10-12

  

  In our previous research, we have focused on the discovery of novel VEGFR-2 inhibitors as anti-angiogenesis agents. Numbers of biphenyl-aryl urea incorporated with salicylaldoxime including BPS-7 have been developed as potent and selective VEGFR-2 inhibitors (Fig. 3) [12], [13], [14], [15], [16], [1

• In the present study we

  2019-10-12

  

  In the present study, we investigated the role of EP1R after ICH and its mechanism of action. We hypothesized that EP1R activation aggravates ICH injury but that its blockade reduces injury through the Src kinases and the MMP-9 signaling pathway. To test this hypothesis, we examined the effects of s

• As retinol was not inducing any

  2019-10-12

  

  As retinol was not inducing any of the isoforms of CYP450 responsible for the bioactivation of paracetamol, we decided to examine retinol\'s effect on renal and hepatic glutathione to determine whether retinol was potentiating hepatotoxicity through a mechanism of glutathione depletion. Studies, uti

• br Transparency document br Acknowledgements We thank Prof B

  2019-10-12

  

  Transparency document Acknowledgements We thank Prof. Barbara Brodsky for valuable comments and discussion. We thank the support of the Tufts start-up fund and the Knez Family Faculty Investment Fund for Y.-S. L, and the Tufts Summer Scholar program for E.C. Introduction Discoidin domain r

• In the present study BACH downregulation did not

  2019-10-12

  

  In the present study, BACH1 downregulation did not correlate with nuclear accumulation of NRF2, suggesting that these changes were triggered via an independent mechanism. BACH1 is a transcriptional repressor that is regulated by heme. Heme binding to the BACH1 C-terminal domain inhibits BACH1 DNA bi

• Immunomodulation effects of certain oxysterols

  2019-10-12

  

  Immunomodulation effects of certain oxysterols were previously shown to depend on activation of oxysterol-binding liver X receptors (LXRs). Recent work from our labs as well as from others has shown additional receptors linking oxysterols and immunity. For example, we found that 7α,25-dihydroxychole

• MdHCLB channels expressed in Xenopus oocytes produced

  2019-10-11

  

  MdHCLB channels expressed in Xenopus oocytes produced currents in response to HA and GABA (Fig. 1, Fig. 3). This is in agreement with the findings with Drosophila HCLB channels (Gisselmann et al., 2004). In the HA concentration-response curves, the effects of GABA were additive to those of HA only i

• Spinal cord injury leads to an

  2019-10-11

  

  Spinal cord injury leads to an extensive inflammatory cascade on spinal cord and the release of pro-inflammatory cytokines can sensitize neurons, activating signaling pathways that will result in thermal and mechanical hypersensitivity [39]. In this regard, Guo and collaborators (2014) demonstrated

• Case report The patient was referred to the

  2019-10-11

  

  Case report The patient was referred to the oral and maxillofacial department at the authors’ institution for further evaluation and treatment. The patient underwent tumor resection with left hemi-mandibulectomy with wide bony margins (Fig. 1A), and mandible reconstruction with fibula free flap and

• A structural explanation for how RBR RING s handle their

  2019-10-11

  

  A structural explanation for how RBR RING1s handle their bound E2~Ubs differently from canonical RINGs has not been readily apparent. Only a few residue positions are strongly conserved in RING and RING1 domains, most of which are zinc-coordinating Cys and histidine residues. A key position in canon

• In conclusion we have found

  2019-10-11

  

  In conclusion, we have found that Egr1 can play an inhibitory role on DBH promoter-driven transcription. This inhibition requires a newly identified Egr1 response IKK-16 hydrochloride at the −227/−224 region of DBH promoter. This inhibition appears to result from Egr1 directly bound to the DBH promo

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