• As a support chitosan presents interesting

  2020-11-09

  

  As a support, chitosan presents interesting characteristics that reinforce its great potential for enzyme immobilization [18,19]. Firstly, it is produced from renewable natural sources in addition to being biodegradable and water insoluble [20,21]. Also, the main peculiarity in the chitosan structur

• CYP contributes to the metabolism of more than

  2020-11-09

  

  CYP450 contributes to the metabolism of more than 90% of currently available drugs (Shapiro and Shear, 2002). Currently, CYP1A is the most studied xenobiotic-metabolizing isoform in fish and is often used as a biomarker for early effects of pollutants in aquatic organisms (Havelkova et al., 2007). T

• Chemokine receptor expression in MCL is shown

  2020-11-09

  

  Chemokine receptor expression in MCL is shown in Table 1. CXCR4, CXCR5 and CCR6 protein was detected in the majority of patients [10], [72], [102], [118] and CX3CR1 was found to be present in up to 75% of cases depending on the method used to identify the receptor [103]. CCR7 was more highly express

• pitavastatin Moving forward the new mathematical model opens

  2020-11-09

  

  Moving forward, the new mathematical model opens doors for understanding the SCF network, where activity of a component is blunted through mutation or altered in expression in diseased states, and during therapeutic intervention. Computational modeling could reveal underappreciated secondary or tert

• The best characterized APC C

  2020-11-09

  

  The best-characterized APC/C substrates are recruited via various linear motifs (e.g., D boxes, KEN boxes, and ABBA motifs) that serve as degrons, binding to distinct regions of the β-propeller domain of a coactivator (Figure 1, Figure 3B) (reviewed in [44]). In addition, D boxes also simultaneously

• br Materials and methods br

  2020-11-09

  

  Materials and methods Results Discussion UPP components including the proteasome, E1s, E2s, E3s and DUBs may become one the most important Pefloxacin of therapeutic targets for the pharmaceutical industry in the near future and supersede those which are involved in the phosphorylation syst

• Indeed the alkyl group is not seen in the original

  2020-11-06

  

  Indeed, the -alkyl group is not seen in the original crystallographic electron density omit map prior to positioning either inhibitor in DHODH, nor can it be found in the final maps. Rather, the electron density maps are consistent with hydrolysis of the amide to the acid. Once the scaffold was clea

• Dgat mice however had less adipose tissue as reflected

  2020-11-06

  

  Dgat−/− mice, however, had less adipose tissue, as reflected by lower total fat pad weights and body triglyceride content. Because of these findings, we hypothesized that, although Dgat−/− mice could make triglycerides through non-DGAT pathway(s), their triglyceride synthesis capacity might not be e

• The second part of this study

  2020-11-06

  

  The second part of this study evaluated the role of CK1 in the eFABP4 cellular uptake in endothelial cells. By blocking CK1 expression using a specific siRNA, we corroborated that the presence of CK1 was fundamental for FABP4 cellular uptake and internalization in endothelial cells, thus decreased m

• Our results for imidacloprid were unexpected considering

  2020-11-06

  

  Our results for imidacloprid were unexpected: considering that imidacloprid (Im) is a neonicotinoid insecticide with a different mode of action (agonist of the nicotinic A-674563 receptor) than OPs, we expected Es-ChE and T-ChE activity to be largely insensitive to changes in Im concentrations. How

• Phenylbenzofurans are a very important

  2020-11-06

  

  Phenylbenzofurans are a very important molecule skeleton due to their synthetic versatility and their proved pharmacological properties [2]. They are synthetic compounds in which an additional phenyl ring is present in any position of the benzofuran nucleus. This could be easily obtained possible by

• As the primary model we selected LDL receptor

  2020-11-06

  

  As the primary model we selected LDL-receptor knockout mice because these resemble the human plasma lipoprotein profile more closely. Currently, genetic models with reduced milk cholesterol content, which mimic cholesterol-free formula feeding, are unavailable. Thus, instead of modifying milk choles

• AON successfully alleviated the myotonic phenotype

  2020-11-06

  

  AON successfully alleviated the myotonic phenotype in DM model mice [18], [23]. To screen for an optimal AON sequence, we used 25-mer phosphorothioate 2′ O-methyl RNA molecules that covered the exon 6B or exon 7A. Unexpectedly, AON 7A (+63−8) which covers the boundary of intron 7A and exon 7A enhanc

• br Materials and methods br Results br Discussion We have

  2020-11-06

  

  Materials and methods Results Discussion We have evaluated the breast cancer prevention potential of PR blockade under conditions that included exposure to progestogens that are relevant to women (progesterone and MPA) and are known to differ in their receptor-binding and down-stream effect

• br Experiments br Numerical simulations br Discussion br

  2020-11-06

  

  Experiments Numerical simulations Discussion Conclusions By large-caliber PELE with various d/D against RHA plate at low velocity of 415 m s−1, impact experiments against 30 mm RHA target were carried out. Numerical simulations were also conducted to monitor progress of PELE expansion an

14593 records 721/973 page Previous Next First page 上5页 721722723724725 下5页 Last page