• For radiochemotherapy it is well known that mitotic cell dea

  2021-05-14

  

  For radiochemotherapy, it is well known that mitotic cell death and apoptosis present the major cell death modes. More recently, autophagy-dependent cell death has been described to occur upon radiochemotherapy (Daido et al., 2005, Song et al., 2017). This form of regulated cell death depends on com

• br Materials and methods br Acknowledgments br Introduction

  2021-05-14

  

  Materials and methods Acknowledgments Introduction Proton pumps convert the energy of high-energy compounds into the toremifene citrate of protons across biomembranes. They play two physiological roles: pH regulation and the formation of proton-motive forces in their membranes. The simples

• We also identified a role for

  2021-05-14

  

  We also identified a role for the transcription factor p53 in the regulation of the Crm1 promoter. p53 can activate or repress the transcription of target genes. While activation generally occurs through binding of p53 to its consensus binding site in the promoter region of target genes, for example

• DDX belongs to the DEAD

  2021-05-14

  

  DDX3 belongs to the DEAD-box family of proteins, ATP-dependent RNA helicases characterized by the presence of a highly conserved helicase core domain [13]. This catalytic core is composed of two RecA-like domains containing motifs involved in ATP binding/hydrolysis, RNA binding and helicase activity

• The significant CRF increase in the

  2021-05-14

  

  The significant CRF increase in the DS and the overall changes in the CRF system observed in the VM and DS during the development of sensitization suggest that this neuropeptide (and possibly urocortin) contributes to the specific molecular alterations occurring in the mesolimbic pathway that suppor

• br Conclusion br Introduction The morphological variability

  2021-05-14

  

  Conclusion Introduction The morphological variability of aquatic plants is well documented, and in some cases has seriously constrained taxonomic resolution (Sculthorpe, 1967, Santamaría, 2002). Many of these variations are caused by the extensive phenotypic plasticity of aquatic plants, but t

• MLN120B australia In rodent models the loss of estrogens thr

  2021-05-14

  

  In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an MLN120B australia receptor beta agonist restores its protective effect, but is abolished with the introduction of a nitric oxide synt

• br O GlcNAc transferase OGT belongs

  2021-05-14

  

  O-GlcNAc transferase OGT belongs to the metal-independent GT-B superfamily of glycosyltransferases, which has been well-reviewed previously [14,15]. OGT is an essential gene encoded on the X-chromosome, and it has two main regions: a long N-terminal tetratricopeptide repeat (TPR) region and a C-t

• Flurbiprofen br Ultrasonic pretreatment of substrates Substr

  2021-05-14

  

  Ultrasonic pretreatment of substrates Substrate pretreatment is widely used in the biofuel, textile and food industries since the substrates are always difficult to degrade. During some enzymatic hydrolysis reactions, the protective layer of the substrate impedes the reaction. Ultrasonic treatmen

• br Materials and methods br Results

  2021-05-14

  

  Materials and methods Results and discussion Concluding remarks Together, the results of the theoretical kinetic simulations and of the analysis of the experimentally determined kinetic data of SoBADH performed in this work show that ignoring substrate inhibition causes potentially importan

• In contrast T bet downregulated the expression of Tfh

  2021-05-14

  

  In contrast, T-bet downregulated the expression of Tfh functional molecules, CD40L, ICOS, and IL-21; accordingly, T-bet overexpression abrogated the helper function of IL-12-stimulated CD4+ T cells. Thus, T-bet seems more involved in the downregulation of the helper functions than in the differentia

• Intriguingly one E residue may serve as a molecular

  2021-05-13

  

  Intriguingly, one E2 residue may serve as a molecular ‘gate’ to allow the C-terminus of ubiquitin to access the closed E2~Ub conformations favorable for ubiquitin transfer. This residue, Asp87 in UbcH5 family members, resides on one side of the opening that leads to the active site Cys (Fig. 4D). In

• Oral antipsychotics are substrates of CYP

  2021-05-13

  

  Oral antipsychotics are substrates of CYP450 enzymes, which are crucial to their metabolism and elimination (Fig. 1). The efficacy and toxicity of antipsychotic agents is affected by factors that induce or inhibit CYP450 expression and function, such as drug–drug interactions. Additionally, the mult

• br Conflicts of interest br Acknowledgements This work

  2021-05-13

  

  Conflicts of interest Acknowledgements This work was supported by funding from Young Sanjin Scholars Distinguished Professor, the Aid Program for Innovation Research Team in Shanxi Agricultural University (CXTD201201), and the Special Fund for Agro-scientific Research in the Public Interest of

• Lipolysis and fatty acid oxidation

  2021-05-13

  

  Lipolysis and fatty Bezafibrate oxidation are two important mechanisms involved in fat reduction. Over stimulation of lipolysis increases the level of FFAs in the serum and causes metabolic perturbation (Koutsari and Jensen, 2006). A large inflow of FFAs to the mitochondria may lead to mitochondria

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