• br Short Communication Free fatty acid receptors

  2021-12-13

  

  Short Communication Free fatty herpes simplex virus 1 receptors (FFAR) play significant roles in energy metabolism (Brown et al., 2005; Ichimura et al., 2009). The receptor FFAR1 is involved in insulin secretion in humans (Meidute Abaraviciene et al., 2013). Activation of the receptor FFAR2 incre

• FBPase deficiency is a very

  2021-12-13

  

  FBPase deficiency is a very rare inborn error of fructose natural aromatase inhibitors of autosomal recessive inheritance. This disorder usually occurs in the first year of life through ketotic hypoglycemia and lactic acidosis triggered by catabolic episodes such as prolonged fasting or febrile inf

• Trifluoromethyl ketones and fluorophosphates were the first

  2021-12-13

  

  Trifluoromethyl ketones and fluorophosphates were the first generation FAAH inhibitors identified. They showed good in vitro FAAH inhibition potency, but most of them exhibited poor selectivity for FAAH over other serine hydrolases (such as the triacylglycerol hydrolase and the membrane-associated h

• PKC does not however directly

  2021-12-13

  

  PKC does not, however, directly stimulate secretion by initiating calcium influx into the cell [51]. Work from multiple groups measuring calcium currents has shown that PMA alone or coupled with glucose does not modulate intracellular calcium influx [34], [51], [52], [53]. Instead of contributing to

• Our results further indicate that low expression

  2021-12-13

  

  Our results further indicate that low expression of p300/CBP in CRC is directly associated with poor clinical therapeutic outcome of 5-FU treatment, potentially providing a new set of biomarkers to predict chemo-sensitivity. Although the ability of low expression of p300/CBP to predict poor prognosi

• The observed tendency for higher plasma lactate

  2021-12-10

  

  The observed tendency for higher plasma lactate levels in the aerated thermal exposure suggests increased reliance on Ciclopirox ethanolamine metabolism to maintain function. This finding is supported by a recent study that observed an increased ṀO2 in European perch (Perca fluviatilis) exposed to

• Introduction Epigenetic mechanisms modulate heritable phenot

  2021-12-10

  

  Introduction Epigenetic mechanisms modulate heritable phenotypic changes that are not dictated by changes in DNA sequences. The link between epigenetic modifications and cancer development has been established [1], [2]. Histone modifications represent an important class of epigenetic mechanisms tha

• Transcriptional translational modulators The discovery that

  2021-12-10

  

  Transcriptional/translational modulators. The discovery that β-lactam antibiotics like ceftriaxone enhance the in vivo expression of EAAT2/GLT-1 [31] has pioneered a completely new approach to EAAT modulation, with several additional EAAT activators following in its trail (Figure 2b) [32, 33, 34•, 3

• br Materials and methods br Results Aberrant A

  2021-12-10

  

  Materials and methods Results Aberrant Aβ has been suggested to be an initiating factor for glutamate excitotoxicity in AD pathology. To investigate whether Aβ1-42 alters glutamate uptake in astrocytes, neurons, and astrocyte-neuron co-cultures, we used synthetic Aβ1-42 peptide. Aβ1-42 has fas

• To discriminate the peripheral and central

  2021-12-10

  

  To discriminate the peripheral and central involvement of FAAH in paracetamol action, we proposed a pharmacological strategy challenging the analgesic action of paracetamol observed in an inflammatory context with either a peripherally-restricted FAAH inhibitor (URB937, Clapper et al., 2010, Moreno-

• The exocytosis promotion is triggered upon

  2021-12-10

  

  The NVP-BSK805 promotion is triggered upon the binding of Ca2+ to the C2 domains of two key protein groups, i.e. complexin and certain synaptogamins (Lai et al., 2017; Rizo and Xu, 2015). The first step of the vesicle fusion is the priming of the secretory vesicles, involved at the switching from cl

• br Discussion The aim of the

  2021-12-10

  

  Discussion The aim of the present study was to extend the list of ASIC ligands and to check if histamine receptors ligands can also affect ASICs. The novel finding is that not only histamine but also thioperamide, 1-metylhistamine and Nα-methylhistamine are active ASIC1a potentiators, while other

• br Introduction br Mitochondrial dysfunction and cancer br

  2021-12-09

  

  Introduction Mitochondrial dysfunction and cancer Lactate and succinate as oncometabolites Intracellular actions of lactate and succinate as tumor promoters Cell-surface receptors for lactate and succinate and their role in cancer GPR109A as the receptor for butyrate and β-hydroxybu

• Introduction The onset of uterine labor

  2021-12-09

  

  Introduction The onset of uterine labor is the culmination of a gradual uterine activation wherein physiological inflammation induces a common prolabor pathway characterized by increased myometrial contractility, weakening of fetal membrane integrity, and cervical ripening. Pathological proinflamma

• Introduction Gestational diabetes mellitus GDM

  2021-12-09

  

  Introduction Gestational diabetes mellitus (GDM) is one of the most common complications associated with pregnancy [1]. Approximately 7.6% of pregnancies in the United States are complicated by GDM [2,3], which significantly increases the mother's risk of developing type 2 diabetes (T2D) later in l

14928 records 507/996 page Previous Next First page 上5页 506507508509510 下5页 Last page