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Results from the current study are not consistent with
2022-01-28
Results from the current study are not consistent with those of a previous study (Poock et al., 2015) where there was no differences in ovulation induction response when there was administration of gonadorelin hydrochloride and gonadorelin diacetate salts. These differences in results are likely due
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In previous work we showed that benzophenanthridines do not
2022-01-28
In previous work we showed that benzophenanthridines do not affect the surface expression of GlyT1 (Jursky and Baliova, 2011). The results from the surface biotinylation studies reported in Fig. 3 show that the surface expression of the Y370F mutant is not significanly affected by the alkaloids in t
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Overall ABC transporters are hypothesised
2022-01-28
Overall, ABC transporters are hypothesised to prevent the penetration of AEDs and other pharmacological compounds into the brain, being a hurdle for therapeutic delivery in neurological diseases. DRE is thought to be in part related to an increased expression of efflux transporters in the BBB, altho
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Throughout the last few decades evidence has
2022-01-28
Throughout the last few decades, evidence has accumulated indicating that NTTs, whose primary location is the cell surface, are subject to a series of regulatory processes of intracellular traffic to and from the membrane (Robinson and Jackson, 2016; Vaughan and Foster, 2013). In addition, lateral m
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br Introduction Most organisms require glucose as a key meta
2022-01-28
Introduction Most organisms require glucose as a key metabolite, and it is critical that mammalian cells regulate glucose levels properly to maintain bioenergetic homeostasis. The major transporters responsible for the uptake of glucose from systemic circulation into cells are the GLUTs, members
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Gap junction intercellular communication GJIC facilitates th
2022-01-27
Gap junction intercellular communication (GJIC) facilitates the exchange of ions, metabolites, Ca2+, inositol phosphates, and/or cyclic nucleotides of up to 1.8 kD in size between Mometasone furoate sale through contact-dependent mechanisms [3,4]. Oocyte growth and development (as depicted in Fig. 1
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Introduction of a chloropyridine group onto the fluoro
2022-01-27
Introduction of a chloropyridine group onto the fluoro derivative (→) leads to a similarly potent compound that exhibits a lower /, and as was observed with (), was rapidly cleared. However, the high clearance of () did not prevent the increase in the concentrations of FAAs even as its plasma levels
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br Retrieval requires histamine H receptors in
2022-01-27
Retrieval requires histamine H1 receptors in dorsal hippocampus Retrieval is a dynamic process that requires neurotransmitter regulation (Barros et al., 2000, Barros et al., 2001). Recently, histamine, and histaminergic transmission has entered the list of putative neurotransmitter modulators of
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br Conflict of interest br Acknowledgement br Exposure
2022-01-27
Conflict of interest Acknowledgement Exposure to tobacco smoke in early life has been found to increase the risk of developing asthma and lung function deficits in adolescence and adulthood., , , , However, not all children exposed to tobacco smoke in early life develop asthma, which suggest
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5(S),6(R)-7-trihydroxymethyl Heptanoate Like tBHQ and DEM tr
2022-01-27
Like tBHQ and DEM, treatment of Keap1+/+ MEFs with SFN increased the abundance of Hmox1 and Nqo1 mRNA, and this was blunted by LY294002 and MK-2206 (Figure 2C). However, unlike the situation with tBHQ and DEM, treatment of Keap1−/− MEFs with SFN did not increase further the elevated basal levels of
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Selection of the month br Fibrosis br Liver protection devic
2022-01-27
Selection of the month Fibrosis Liver protection device Non-alcoholic steatohepatitis Genetic metabolic liver disease Hepatitis C virus (HCV) infection Hepatitis B virus (HBV) infection Cirrhosis Regeneration Introduction Upon catalysis by hepatic and bacterial enzymes, c
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The fact that KNDy neurons activity is sensitive
2022-01-27
The fact that KNDy neurons activity is sensitive for circulating hormones related with control of Cy5 amine (non-sulfonated) homeostasis was demonstrated in other studies (Cejudo Roman et al., 2012; Navarro et al., 2011). It is well documented that leptin plays an important role in the regulation o
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Compared to previously reported atypical N glycosites that
2022-01-27
Compared to previously reported atypical N-glycosites that were identified based on the deamidation of asparagine residues after PNGase F treatment [106], [107], these two studies further validated the identified atypical motif glycosites by directly identifying their intact glycopeptides. Since the
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Indeed our immunohistochemical analysis of skin tissue sampl
2022-01-26
Indeed, our immunohistochemical analysis of skin tissue samples without any pathology confirmed the expression of MR and GR. Extending earlier findings in rats (Shaqura et al., 2016a, Shaqura et al., 2016b), we demonstrate here that MR mainly colocalize with the nociceptive neuronal marker CGRP sugg
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Cx has been shown to be serine
2022-01-26
Cx45 has been shown to be serine phosphorylated by CaMKII, CK1, PKA, and MAPK in HeLa Ropivacaine HCl [77], [78]. Phosphorylation by PKA and MAPK were associated with decreased junctional conductance [78], suggesting that phosphorylation of Cx45 may influence conduction properties. Overall, the rol
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