• br Conflict of interest br Introduction Milk

  2022-06-30

  

  Conflict of interest Introduction Milk and dairy products are nutritious foods that provide lactose, calcium, phosphorous, magnesium and proteins, among other nutrients, which have been reported to have a fundamental role in bone development and healthy diets. An adequate consumption of dairy

• yohimbine hydrochloride We note that zinc speciation at and

  2022-06-30

  

  We note that zinc speciation at and 2 mol. equiv. of myristate is already markedly different; this means that FFAZn2+ crosstalk is in operation under normal physiological conditions. At present, there are few data to allow tracking of the effects of such physiological crosstalk, although there are s

• tachykinin In the present studies we found

  2022-06-30

  

  In the present studies, we found that genistein did not antagonize fMLF-induced Ca2+ mobilization in FPR1-HL60 tachykinin and human neutrophils. Thus, the previously reported inhibitory effect of genistein on fMLF-stimulated degranulation, aggregation, and reactive oxygen species (ROS) production in

• br Materials and methods br Acknowledgments We are

  2022-06-30

  

  Materials and methods Acknowledgments We are grateful for financial support from the National Natural Science Foundation of China (Grants No. 81661148046 and 81773762, China) and the “Personalized Medicines—Molecular Signature-based Drug Discovery and Development”, Strategic Priority Research

• br Conclusion Discovery of an ideal orally active

  2022-06-30

  

  Conclusion Discovery of an ideal orally active antithrombotic drug has remained elusive till date. Research efforts in this direction led to the discovery of numerous coagulation enzyme inhibitors including various thrombin and FXa inhibitors. Several preclinical studies have highlighted the impo

• The present study was designed to clarify the distribution

  2022-06-30

  

  The present study was designed to clarify the distribution and the function of the endothelin receptors in the guinea-pig urinary bladder. We found that endothelin-1 produced a clear tonic contraction via both hoechst stain receptor subtypes, the endothelin ETA and ETB receptor, and that sarafotoxi

• br Methods br Results br Discussion In

  2022-06-30

  

  Methods Results Discussion In the general population BNP has been established as a marker for latrunculin a receptor failure diagnosis. Moreover, there is growing evidence that elevated levels of natriuretic-peptides may improve CV risk prediction in the general population above traditional

• Introduction Histamine Imidazolyl ethylamine is an important

  2022-06-30

  

  Introduction Histamine [2-(4-Imidazolyl)-ethylamine] is an important mediator of many physiological and pathological processes including inflammation, gastric ARRY334543 secretion, neuromodulation, regulation of immune function, cell proliferation and differentiation, among others. Histamine exert

• CTGF is an established YAP TAZ target

  2022-06-30

  

  CTGF is an established YAP/TAZ target gene which plays a central role in tissue remodeling. Downregulation of CTGF mediates collagen loss in chronologically-aged human skin whereas persistent activation of CTGF can result in excessive deposition of collagen and fibrotic disorders [63]. The authors f

• Introduction Breast cancer is the most common cancer

  2022-06-30

  

  Introduction Breast cancer is the most common cancer among women worldwide, representing 30% of new cancer diagnoses. In addition, it is the second leading cause of cancer deaths among women [1]. With regard to the risk of breast cancer, proper diagnosis and stratification of tumors for individuali

• br Materials and methods br Author

  2022-06-30

  

  Materials and methods Author contributions Acknowledgments We thank members of the Skaar laboratory for critical evaluation of the manuscript. This work was supported by grants from the National Institutes of Health, R01AI069233 (EPS), and T32GM008554-21 (LJL). Introduction Pseudomonas

• The relaxant response to carperitide was influenced neither

  2022-06-30

  

  The relaxant response to carperitide was influenced neither by the removal of the endothelium nor by treatment with the nitric oxide synthase inhibitor or nitric oxide scavenger. This result was to be expected as previous studies showing that the vasodilator action of atrial natriuretic peptide is e

• As natural ligands of GPR

  2022-06-29

  

  As natural ligands of GPR120, several long chain polyunsaturated fatty acids (Lc-PUFAs) have been demonstrated to modulate the 3T3-L1 adipogenic differentiation. However, the effects of the Lc-PUFAs are inconclusive. DHA is shown to inhibit, promote or even not affect the differentiation of preadipo

• br RNA preparation cDNA synthesis

  2022-06-29

  

  RNA preparation, cDNA synthesis and RT-PCR Trizol reagent (Invitrogen, Carlsbad, CA, USA) was used to extract total RNA from tissues according to the manufacturer’s protocol and isolated RNA quantity was determined by UV spectrophotometry (Nanodrop, Thermo Scientific, USA) and RNA integrity was v

• br Results and discussion A diverse set of compounds

  2022-06-29

  

  Results and discussion A diverse set of compounds were synthesized to improve the PK and physicochemical properties of 2. Compounds' agonist effects on hGPR40 were assessed by calcium mobilization assay using hGPR40-HEK293 cell line which stably expressed human GPR40. Preliminary explorations fo

14980 records 394/999 page Previous Next First page 上5页 391392393394395 下5页 Last page