• br Results br Discussion By using an unbiased proteomic

  2022-11-03

  

  Results Discussion By using an unbiased proteomic screen for xCT binding partners, followed by functional validation, we have made the surprising discovery that mTORC2 regulates amino tgf beta receptor 1 metabolism in tumor cells by phosphorylating serine 26 of the cystine-glutamate antiporte

• br Materials and methods br Results br

  2022-11-03

  

  Materials and methods Results Discussion Knowledge of the molecular basis of an inherited genetic disease is crucial for understanding the disease pathology and, ultimately, for therapeutic design. Several recent reports have stressed the need for physical characterization of disease-associ

• In this study we demonstrated that DRR

  2022-11-03

  

  In this study, we demonstrated that DRR1 protein level in GBM tissues was significantly higher compared to normal b 35 tissues. This data suggested that DRR1 might play a role in the tumorigenesis of glioma. To investigate whether DRR1 could accurately predict the outcome in patients with glioma, I

• br Conclusion br Conflict of interest br

  2022-11-03

  

  Conclusion Conflict of interest Acknowledgments We thank Nancy Kerkvliet for helpful advice. The research in the lab of CE and THS is supported by the Deutsche Forschungsgemeinschaft (grants ES103/7-1 and 9-1, HA7346/2-1). We apologize to all authors whose work could not be cited due to lim

• Ketogenic diets are more effective in promoting

  2022-11-03

  

  Ketogenic diets are more effective in promoting weight loss than conventional caloric restriction [26] however, their effect on hepatic glucose and lipid metabolism remains inconclusive. Blood glucose homeostasis is tightly regulated. In both mice and humans consuming KD, baseline blood glucose decr

• br Functional consequences of ADK regulation on neuronal exc

  2022-11-03

  

  Functional consequences of ADK regulation on neuronal excitability Adenosine modulates neuronal excitability via activation of the high affinity A1 or A2A, low-affinity A2B, or low abundance A3 adenosine receptors that feed into a multitude of different neuronal and astrocytic pathways (Blum et a

• br Methods and results ACE is

  2022-11-03

  

  Methods and results ACE is a Canadian satellite mission [7] that measures atmospheric BINA spectra in the limb geometry using the Sun as a light source (solar occultation). The ACE orbit (74° inclination to the equator, 650 km altitude) concentrates measurements at high latitudes but also provid

• Introduction Lysophosphatidic acid LPA is a key serum borne

  2022-11-03

  

  Introduction Lysophosphatidic p m x (LPA) is a key, serum-borne phospholipid, regulating a number of cellular processes such as proliferation, migration and differentiation through its interaction with G-protein coupled receptors. LPA receptor signaling has been implicated in several disease state

• Screening a selection of analogues from this library against

  2022-11-03

  

  Screening a selection of analogues from this library against the panel of 26 kinases (16, 22, and 24 were screened at 30 μM due to poor solubility; 17 tested at 100 μM) generally demonstrated an increase in activity compared to 3,4-DAA mg 3 (Fig. 3, Fig. 6). The benzamide analogue 16 demonstrated >5

• The ambiguity surrounding the role played

  2022-11-03

  

  The ambiguity surrounding the role played by the 15-LOXs in malignant biological processes stems also from the limitations of current animal models, and especially the usage of its 12/15-LOX murine homolog, which can also catalyze the production of 12-HETE. Indeed, the proinflammatory effect of 12-H

• Because ASK signaling in microglia and astrocytes

  2022-11-03

  

  Because ASK1 signaling in microglia and astrocytes is important during EAE, we hypothesized that a combination therapy that targets T cells along with microglia and astrocytes would further ameliorate the severity of EAE. We tested this hypothesis by applying valproic iox receptor (VPA)—a short-cha

• It is now well established that the

  2022-11-03

  

  It is now well established that the cumulative exposure to endogenous estrogens throughout a woman's life, mainly due to her reproductive history, has an impact on the risk of hormone-dependent breast cancer (Lambertini et al., 2016). Prolonged exposure to estrogens in the case of early age at menar

• br Epidemiology br Genetics The dominantly inherited PrP cer

  2022-11-02

  

  Epidemiology Genetics The dominantly inherited PrP cerebral amyloidoses are genetically transmitted with a penetrance of almost 100%. Early linkage analysis studies helped to established the relationship between GSS and mutations in the PRNP gene. PRNP is located on the short arm of chromosome

• Liao and van Linden et al divided

  2022-11-01

  

  Liao [47] and van Linden et al. [48] divided the gap between the N-terminal and C-terminal lobes into a front cleft or pocket, a gate area, and a back cleft. The back pocket corresponds to the gate area and the back cleft. The front cleft includes the Gly-rich loop, the hinge, the linker connecting

• Polycyclic aromatic hydrocarbons PAHs are abundant environme

  2022-11-01

  

  Polycyclic aromatic hydrocarbons (PAHs) are abundant environmental contaminants that are produced by the incomplete combustion of organic matter, combustion engines, residential heating, Gemcitabine HCl burning, and industrial activities (Gelboin, 1980; Phillips, 1999, Phillips, 2002). Some PAHs ha

14980 records 346/999 page Previous Next First page 上5页 346347348349350 下5页 Last page