• br Perspective AA LA and other

  2023-08-14

  

  Perspective AA, LA and other PUFAs and their lipid metabolites play an important role in human diseases. 12/15-LOX which is the metabolic enzyme of them plays an important role in the pathogenesis-related diseases such as atherosclerosis, diabetic nephropathy, neurological diseases and other path

• The rescue of the behavioral deficit was associated

  2023-08-14

  

  The rescue of the behavioral deficit was associated with a significant reduction in the levels of both soluble and insoluble Aβ peptides and their deposition in the Fenofibric acid of the same animals. In search for the mechanism behind the reduced amyloidosis, we assessed APP metabolism. Confirmin

• br Introduction The structural similarities

  2023-08-14

  

  Introduction The structural similarities between puromycin (1, Fig. 1) and the aminoacyl adenyl terminal of aminoacyl–tRNA allow it to terminate the protein synthesis process by causing premature release of a polypeptide from the ribosome [1], [2]. Tremendous progress in the study of puromycin an

• 9-cis-Retinoic Acid Although several ARIs have reached vario

  2023-08-14

  

  Although several ARIs have reached various phases of clinical experimentation however most of them have been withdrawn either due to an insufficient bioavailability, their poor efficacy or adverse side effects. Currently Epalrestat is in clinical use for the treatment of diabetic neuropathy. The sid

• For the first series we decided

  2023-08-14

  

  For the first series we decided to verify the effects induced, on the ALR2 inhibitory properties, of an additional steric hindrance on the carbon in α position with respect to the carboxylic group, by introducing a methyl group (R2=Me). Therefore, we synthesized a series of new α-alanine derivatives

• 17-ODYA australia Since the first studies of betaine aldehyd

  2023-08-14

  

  Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other 17-ODYA australia as betaine homocysteine methyltransferase and methionine synthase. But, there is a lack of at

• Cancer stem cells CSCs may have been

  2023-08-14

  

  Cancer stem cells (CSCs) may have been first identified in teratocarcinomas [11], [12], with its initial clues date back to the 19th century [13]. Kleinsmith and Pierce [12] established the immortal pluripotent teratocarcinoma lines from a single transplanted multi-potent malignant cell, strongly su

• br Conflict of interest br Acknowledgements We would

  2023-08-14

  

  Conflict of interest Acknowledgements We would like to thank Editage (www.editage.jp) for English language editing. This work was supported by Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant Number 24592576. Co-existence of β- and β-adrenergic recept

• Our previous work fails to

  2023-08-14

  

  Our previous work fails to show any maternal effect with blockade of 5-HT2A receptor, as acute and repeated treatment of MDL100907 does not alter maternal behavior at the behaviorally active doses (Chen et al., 2014). In the present study, MDL100907 pretreatment attenuated the maternal disruptive ef

• br Results br Discussion Today enzymes

  2023-08-14

  

  Results Discussion Today, enzymes play important roles in various fields. A good assay for enzyme activity is of great value, especially when it has good specificity, sensitivity, reproducibility and economy. ADK is the first identified enzyme in the metabolic pathway of adenosine salvage [15,

• We have previously reported that interfering with actin asse

  2023-08-14

  

  We have previously reported that interfering with BIIE 0246 sale assembly dynamics by knocking down cofilin-1 in hMSCs increased polymerized actin that promoted osteoblast cell differentiation through a mechanism of enhancing focal adhesion kinase (FAK), p38 and c-Jun N-terminal kinase (JNK) signal

• br Introduction ACK or Activated Cdc Associated Kinase

  2023-08-14

  

  Introduction ACK1, or Activated Cdc42-Associated Kinase, located on chromosome 3q, is a ubiquitously expressed non-receptor tyrosine kinase cloned from a human ionomycin australia cDNA library (Manser et al., 1993). It was first identified to bind to activated Cdc42, a small Ras GTPase via its C

• There has been growing interest over computational methods t

  2023-08-14

  

  There has been growing interest over computational methods to predict the biological activity by chemical structure, so as to decide whether it Octreotide acetate has objective qualities or not. In this contribution, the well-known method, which is called quantitative structure–activity relationshi

• br ACh and ER tests hereafter Spasm provocation tests have

  2023-08-14

  

  ACh and ER tests hereafter Spasm provocation tests have self-limitations to document coronary artery spasm during daily life. In the past reports, ST elevation was reproducible in some patients with variant 4-Methylhistamine dihydrochloride receptor by the administration of ACh or ER. However, we

• Concerning asthma in a study evaluating the effect of

  2023-08-14

  

  Concerning asthma, in a study evaluating the effect of tiotropium in severe asthma, the sputum eosinophil count and exhaled nitric oxide were also assessed. However, evaluation of the anti-inflammatory effect of tiotropium was difficult because these markers were low at baseline and thereafter. In a

15100 records 299/1007 page Previous Next First page 上5页 296297298299300 下5页 Last page